Orthopedic Complications and Management in Children with X-Linked Hypophosphatemia
نویسندگان
چکیده
X-linked hypophosphatemia is an inheritable disease of renal phosphate wasting that results in clinically manifestations associated with rickets or osteomalacia. The various symptoms the skeletal system are well recognized, such as short stature; lower limb deformities; and bone, joint, muscle pain, it often difficult to control these symptoms, despite use medication therapy growing children. In addition, deformities can lead degenerative osteoarthritis dysfunction limbs at maturity. To prevent from future manifestation those orthopedic surgeries applicable patients severe without response conventional medication. Bone treated by acute gradual corrective osteotomies temporally hemiepiphysiodesis using guided growth method. clinicians should choose right procedure based on age, state patient.
منابع مشابه
X-linked hypophosphatemia with enthesopathy.
Pal R, Bhansali A. BMJ Case Rep 2017. doi:10.1136/bcr-2017-220920 Description A 42-year-old man presented with lower limb bowing since childhood along with low backache and proximal muscle weakness for 8 years. He had strong family history of similar complaints in his elder brother, younger sister and daughter. Examination revealed loss of teeth and genu varum. Investigations showed corrected s...
متن کاملDental management of patients with X-linked hypophosphatemia
X-linked hypophosphatemia (XLH) is a hereditary metabolic disease caused by the loss of phosphate through the renal tubules into the urine, and an associated decrease in serum calcium and potassium phosphate. Its dental features include spontaneous dental abscesses that occur in the absence of trauma or dental caries. The aim of this case report was to describe the dental problems of XLH patien...
متن کاملX-linked hypophosphatemia: dental and histologic findings.
The recurrent spontaneous formation of abscesses affecting multiple noncarious primary as well as permanent teeth is the principle clinical dental feature in cases of hypophosphatemia, a condition inherited through the X chromosome. Patients often have high pulp horns, large pulp chambers and dentinal clefts. We report a case of hypophosphatemic vitamin D-resistant rickets in a patient who repo...
متن کاملThiazide diuretics arrest the progression of nephrocalcinosis in children with X-linked hypophosphatemia.
OBJECTIVE X-linked hypophosphatemia (XLH) is characterized clinically by rickets, hypophosphatemia, and hyperphosphaturia. Conventional treatment of XLH with oral phosphate and vitamin D is associated with increased urinary calcium excretion and nephrocalcinosis. Thiazide diuretics decrease urinary calcium excretion. The objective of this study was to determine the effect of thiazide diuretics ...
متن کاملYALE CENTER FOR X-LINKED HYPOPHOSPHATEMIA Pilot & Feasibility Program A study of enthesopathy in X-linked hypophosphatemia
Dr. Macica states: “The formation of enthesophytes was our focus, with a major emphasis on characterizing the cellular changes that occur in enthesophyte formation using the murine model of XLH, Hyp mice. We have found that mineralization, while thought to originate from bone, is actually due to both an expansion of fibrocartilage cells that express the FGFR3 receptor and an increase in alkalin...
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ژورنال
عنوان ژورنال: Endocrines
سال: 2022
ISSN: ['2673-396X']
DOI: https://doi.org/10.3390/endocrines3030039